The Human Microbiota and Human Chronic Disease : Dysbioses as a Cause of Human Pathology (2016, E-book) by read book EPUB, TXT
9781118982891 English 1118982894 Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity - periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major 'idiopathic' diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. - Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota - Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition - Explores the relationship humans have with their microbiota, and its significance in human health and disease - Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases. About the Authors Luigi Nibali is a Senior Clinical Lecturer in the Clinical Oral Research Centre, Institute of Dentistry, Queen Mary University London in London, UK. Brian Henderson is a Professor of Microbial Diseases in the School of Life and Medical Sciences at University College London in London, UK., The human organism comprises 1013 eukaryotic cells, divided into a large number of distinct organs and tissues, with unimaginable requirements for inter- and intra-cellular communication. Malfunction in such communication inevitably results in the state we define as human disease. The emergent properties of the eukaryotic cellular complexity in "Homo sapiens" were beginning to be suspected in the 1950s and 1960s, at a time when it was becoming clear that the bacteria that actually existed within the healthy human could have a major influence on many of its cellular and tissue systems, including innate and adaptive immunity. The development of antibiotic resistance in the 1970s, produced a renaissance in Microbiology which revealed just how heavily colonised healthy vertebrates were with bacteria. The human appears to be the "acme" of this colonisation process and it is now a familiar expression that 'for every human cell in our bodies there are ten bacteria'. Not only are we colonised by around 1014 bacteria, the human population carries round with it a diversity of bacterial phylotypes that swamps the diversity of all the species in the aggregate of the World's zoological collections. Thus we can no longer think of bacteria in terms of 'us' and 'them'. "Homo sapiens," like most vertebrates, has to be viewed as a supra organism colonised, on its mucosal surfaces and on the skin (and who knows where else), with complex populations of bacteria, with each individual having a unique mixture of these bacteria, presumably a result of genetic (and/or epigenetic) factors controlling commensal bacterial colonisation and the stability of such colonisation. Not only are we colonised by a large and diverse collection of bacteria (this volume will ignore colonisation by single celled eukaryotes and by Archaea), these bacteria are generally in the form of dynamic multi-species biofilms which, like the comparison of human tissues to the disaggregated cells of these tissues, have emergent properties. Thus the collection of microbes in our bodies, which we call the microbiota, is a dynamically complex collection of multi-species biofilms. The formation of these biofilms will require an inordinate amount of intercellular signalling and this signalling must reciprocate with the cellular surfaces on which these biofilms co-exist. These cellular surfaces are 'us'. In the 21st Century, the concept of human health and disease has to take into account the intimate relationship that we must have with our microbiota. The regional complexity of the human microbiota is only now emerging with the application of bacterial phylogenetic analyses through the use of next generation sequencing (NGS) methodologies. This overcomes the problem that only around 50% of the bacteria colonising the human can be cultivated and studied. Each of us is colonised with hundreds of bacterial phylotypes, with each phylotype itself being composed of a varied range of strains, each containing different populations of genes. This generates the concept of the pan-genome with each bacterial pan-genome perhaps having as many protein-coding genes as does its host. This means that the individual bacterial populations colonising each human has 10-100, or more, times the number of genes that is utilised by the host. Every human host is colonised by a different combination of microbes, making him/her more or less susceptible to disease. Host genetic variants are largely responsible for determining the composition of human microbial biofilms. This creates a level of complexity that is difficult to comprehend, and one that needs to be fully explored if we are to understand the healthy human and the diseases s/he is susceptible to. However, the determination, starting in the 1980s, of how enormously colonised we are by bacteria, and the potential bacteria have for interfering with all aspects of our cellular homeostasis, has brought the bacterium, centre stage, as a causative f
9781118982891 English 1118982894 Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity - periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major 'idiopathic' diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. - Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota - Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition - Explores the relationship humans have with their microbiota, and its significance in human health and disease - Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases. About the Authors Luigi Nibali is a Senior Clinical Lecturer in the Clinical Oral Research Centre, Institute of Dentistry, Queen Mary University London in London, UK. Brian Henderson is a Professor of Microbial Diseases in the School of Life and Medical Sciences at University College London in London, UK., The human organism comprises 1013 eukaryotic cells, divided into a large number of distinct organs and tissues, with unimaginable requirements for inter- and intra-cellular communication. Malfunction in such communication inevitably results in the state we define as human disease. The emergent properties of the eukaryotic cellular complexity in "Homo sapiens" were beginning to be suspected in the 1950s and 1960s, at a time when it was becoming clear that the bacteria that actually existed within the healthy human could have a major influence on many of its cellular and tissue systems, including innate and adaptive immunity. The development of antibiotic resistance in the 1970s, produced a renaissance in Microbiology which revealed just how heavily colonised healthy vertebrates were with bacteria. The human appears to be the "acme" of this colonisation process and it is now a familiar expression that 'for every human cell in our bodies there are ten bacteria'. Not only are we colonised by around 1014 bacteria, the human population carries round with it a diversity of bacterial phylotypes that swamps the diversity of all the species in the aggregate of the World's zoological collections. Thus we can no longer think of bacteria in terms of 'us' and 'them'. "Homo sapiens," like most vertebrates, has to be viewed as a supra organism colonised, on its mucosal surfaces and on the skin (and who knows where else), with complex populations of bacteria, with each individual having a unique mixture of these bacteria, presumably a result of genetic (and/or epigenetic) factors controlling commensal bacterial colonisation and the stability of such colonisation. Not only are we colonised by a large and diverse collection of bacteria (this volume will ignore colonisation by single celled eukaryotes and by Archaea), these bacteria are generally in the form of dynamic multi-species biofilms which, like the comparison of human tissues to the disaggregated cells of these tissues, have emergent properties. Thus the collection of microbes in our bodies, which we call the microbiota, is a dynamically complex collection of multi-species biofilms. The formation of these biofilms will require an inordinate amount of intercellular signalling and this signalling must reciprocate with the cellular surfaces on which these biofilms co-exist. These cellular surfaces are 'us'. In the 21st Century, the concept of human health and disease has to take into account the intimate relationship that we must have with our microbiota. The regional complexity of the human microbiota is only now emerging with the application of bacterial phylogenetic analyses through the use of next generation sequencing (NGS) methodologies. This overcomes the problem that only around 50% of the bacteria colonising the human can be cultivated and studied. Each of us is colonised with hundreds of bacterial phylotypes, with each phylotype itself being composed of a varied range of strains, each containing different populations of genes. This generates the concept of the pan-genome with each bacterial pan-genome perhaps having as many protein-coding genes as does its host. This means that the individual bacterial populations colonising each human has 10-100, or more, times the number of genes that is utilised by the host. Every human host is colonised by a different combination of microbes, making him/her more or less susceptible to disease. Host genetic variants are largely responsible for determining the composition of human microbial biofilms. This creates a level of complexity that is difficult to comprehend, and one that needs to be fully explored if we are to understand the healthy human and the diseases s/he is susceptible to. However, the determination, starting in the 1980s, of how enormously colonised we are by bacteria, and the potential bacteria have for interfering with all aspects of our cellular homeostasis, has brought the bacterium, centre stage, as a causative f